This is a list of guest stars who appeared in Season 6 of Hot Ones:
| Guest star | Appears in |
|---|---|
| Johnny Knoxville | Episode 1 |
| Natalie Portman | Episode 2 |
| Marques Brownlee | Episode 3 |
| Joel Embiid | Episode 4 |
| Tom Segura | Episode 5 |
| Joji and Rich Brian | Episode 6 |
| Wiz Khalifa | Episode 7 |
| Al Roker | Episode 8 |
| Michael Cera | Episode 9 |
| Issa Rae | Episode 10 |
| Rhett & Link | Episode 11 |
| Jeff Goldblum | Episode 12 |
| Eddie Huang | Episode 13 |