This is a list of hot sauces that appeared in Season 5 of Hot Ones:
| No. | Sauce | Scoville units |
|---|---|---|
| 1 | Humble House Ancho & Morita | 450 |
| 2 | Original Louisiana Hot Sauce | 550 |
| 3 | Small Axe Peppers – The Bronx Greenmarket Hot Sauce | 5,500 |
| 4 | Hot Ones – Fiery Chipotle | 15,600 |
| 5 | Adoboloco Hawaiian Hot Sauce Hamajang Kiawe Smoked Ghost Pepper | 32,000 |
| 6 | Karma Sauce Extreme Karma | 56,000 |
| 7 | Dawson's Original Hot Sauce | 82,000 |
| 8 | Da' Bomb Beyond Insanity | 135,600 |
| 9 | Mad Dog 357 – 25th Anniversary Edition | 1,000,000 |
| 10 | Hot Ones – The Last Dab (Reaper Edition) | 2,000,000+ |