This is a list of guest stars who appeared in Season 4 of Hot Ones:
| Guest star | Appears in |
|---|---|
| Cara Delevingne | Episode 1 |
| Liam Payne | Episode 2 |
| Steve-O | Episode 3 |
| Vince Staples | Episode 4 |
| Adam Richman | Episode 5 |
| ASAP Ferg | Episode 6 |
| Kevin Durant | Episode 7 |
| Henry Rollins | Episode 8 |
| Dillon Francis | Episode 9 |
| Joji | Episode 10 |
| Wanda Sykes | Episode 11 |
| Terry Crews | Episode 12 |
| Gary Vaynerchuk | Episode 13 |
| Artie Lange | Episode 14 |
| Chris Jericho | Episode 15 |
| Gabrielle Union | Episode 16 |
| Wale | Episode 17 |
| Bob Saget | Episode 18 |
| Mario Batali | Episode 19 |
| Alexa Chung | Episode 20 |
| Logic | Episode 21 |
| Casey Neistat | Episode 22 |
| Chili Klaus | Episode 24 |