This is a list of guest stars who appeared in Season 2 of Hot Ones:
| Guest Star | Appears in |
|---|---|
| Curren$y | Episode 1 |
| Tinashe | Episode 2 |
| Tommy Chong | Episode 3 |
| T.J. Miller | Episode 4 |
| Coolio | Episode 5 |
| Joey Fatone | Episode 6 |
| Michael Rapaport | Episode 7 |
| Key & Peele | Episode 8 |
| Riff Raff | Episode 9 |
| Eddie Huang | Episode 10 |
| Chris D'Elia | Episode 11 |
| Mike Epps | Episode 12 |
| Jim Gaffigan | Episode 13 |
| Carly Aquilino | Episode 14 |
| Redman | Episode 15 |
| Rob Gronkowski | Episode 16 |
| Rob Corddry | Episode 17 |
| Jeff Ross | Episode 18 |
| David Cross | Episode 19 |
| Eric André | Episode 20 |
| Joe Budden | Episode 21 |
| Matty Matheson | Episode 22 |
| RZA & Paul Banks | Episode 23 |
| Bert Kreischer | Episode 24 |
| YG | Episode 25 |
| Jay Pharoah | Episode 26 |
| Harley Morenstein | Episode 27 |
| Travis Kelce | Episode 28 |
| Hasan Minhaj | Episode 29 |
| Kevin Hart | Episode 30 |
| Martin Garrix | Episode 31 |
| Bobby Lee | Episode 32 |
| Tony Hawk | Episode 33 |
| Action Bronson | Episode 34 |
| T-Pain | Episode 35 |
| Rachael Ray | Episode 36 |
| Tom Colicchio | Episode 37 |
| Post Malone | Episode 38 |
| N.O.R.E. | Episode 39 |
| James Franco & Bryan Cranston | Episode 40 |