This is a list of guest stars who appeared in Season 19 of Hot Ones:
| Guest star | Appears in |
|---|---|
| David Blaine | Episode 1 |
| Kid Cudi | Episode 2 |
| Viola Davis | Episode 3 |
| Cole Bennett | Episode 4 |
| Cate Blanchett | Episode 5 |
| Emma Chamberlain | Episode 6 |
| James Corden | Episode 7 |
| Ramy Youssef | Episode 8 |
| Israel Adesanya | Episode 9 |
| Zoe Saldaña | Episode 10 |
| Kate Hudson | Episode 11 |
| Paul Dano | Episode 12 |