This is a list of guest stars who appeared in Season 10 of Hot Ones:
| Guest star | Appears in |
|---|---|
| Shia LaBeouf Sheds | Episode 1 |
| Ashton Kutcher | Episode 2 |
| Noel Gallagher | Episode 3 |
| Liza Koshy | Episode 4 |
| Paul Rudd | Episode 5 |
| Maisie Williams | Episode 6 |
| Nick Offerman | Episode 7 |
| DaBaby | Episode 8 |
| Kristen Stewart | Episode 9 |
| Chance the Rapper | Episode 10 |
| Brad Leone | Episode 11 |
| John Boyega | Episode 12 |