The guests who were unable to consume all ten wings on Hot Ones include:
- Tony Yayo (Season 1)
- DJ Khaled (Season 1)
- Ice Spice (Season 23)
- Eddie Huang (on his first appearance - Season 2)
- Mike Epps (Season 2)
- Jim Gaffigan (Season 2)
- Rob Corddry (Season 2)
- Ricky Gervais (Season 3)
- Mario Batali
- Taraji P. Henson (Season 5)
- Lil Yachty (Season 7)
- E-40 (Season 7)
- Chance the Rapper (Season 10)
- Eric André (on his second appearance)
- Quavo (Season 15)
- Pusha T (Season 17)
- Venom
- Shaquille O’Neal (Season 7)